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Multimicroparticulate pharmaceutical forms foe oral administration
专利权人:
发明人:
Florence Guimberteau,Frederic Dargelas
申请号:
US15132974
公开号:
US20160338966A1
申请日:
2016.04.19
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The object of the present invention is to minimize the risks of dose dumping associated with the concomitant consumption of alcohol and certain modified-release pharmaceutical or dietetic forms.The invention relates to an oral form comprising microparticles of the reservoir type for the modified release of at least one active principle (AP), characterized in that it is resistant to immediate dumping of the dose of AP in the presence of alcohol. In particular, the oral form according to the invention is characterized in that the time taken to release 50% of the AP in an alcoholic solution is not reduced more than 3-fold relative to the time taken to release 50% of the AP in an alcohol-free aqueous medium.The form comprises an agent D, which is a pharmaceutically acceptable compound whose hydration or solvation rate or capacity is greater in an alcohol-free aqueous medium than in alcoholic solution.
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