YOU, Seung Kwon,유승권,ZHENG, Jie,정걸,GAO, Wei Wei,고위위,JANG, Ji Hoon,장지훈,JUN, Eun Kyoung,전은경,YOON, Byung Sun,윤병선,KANG, Phil Jun,강필준,SON, Da Ryeon,손다련,HONG, Won Jun,홍원준,YUN, Won Jin,윤원진,LEE, Jang Bo,이장보,PA
申请号：
KRKR2019/011014
公开号：
WO2020/045990A1
申请日:
2019.08.28
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a method for inducing a de-differentiation of neural stem cells from urine cells by introducing mRNAs of de-differentiation factors Oct4, Sox2, Klf4, and Glis1； and a composition for the prevention or treatment of neurological damage diseases comprising the neural stem cells induced by the method as an active ingredient.La présente invention concerne un procédé pour induire une dé-différenciation de cellules souches neurales à partir de cellules urinaires par introduction d'ARNm de facteurs de dédifférenciation Oct4, Sox2, Klf4 et Glis1； et une composition pour la prévention ou le traitement de maladies de lésion neurologique comprenant les cellules souches neurales induites par le procédé en tant que principe actif.본 발명은 역분화 인자 Oct4, Sox2, Klf4 및 Glis1의 mRNA를 도입하여 소변세포로부터 신경줄기세포의 역분화 유도 방법 및 상기 방법에 의해 유도된 신경줄기세포를 유효성분으로 하는 신경 손상 질환 예방 또는 치료용 조성물에 관한 것이다.
