Methods for treating immune-mediated dengue fever infections and antibody-dependent enhancement of dengue fever infections, including dengue hemorrhagic fever and dengue shock syndrome

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专利权人:

INC.;TRINITY THERAPEUTICS

发明人:

Bodie, Neil M.

申请号：

AU2009270805

公开号：

AU2009270805B2

申请日:

2009.07.17

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, are described. For example, polypeptides and other compounds can be used to inhibit binding of DF-associated, immune-complexed IgG anti-DF viron(s) or DV viral antigens to F&gamma；R, ADE of DF/DHF/DSS infections by inhibition of DF viral antigen binding to immune complexed IgG, F&gamma；R and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/