The present invention provides an erythropoietin - derived peptide having an amino acid sequence shown in ID 1. present also des method preparing the above - described erythropoietin - derived peptide. Also provided is the use of the above - described - derived for preparation a for 5 treating nerve cell damage. Also provided is the use of th e above - described erythropoietin - derived peptide for the preparation of a medicament for treating hypoxic brain damage. Also provided is the use of the above - described erythropoietin - derived peptide for the preparation of a medicament for treating epilepsy . The novel EPO - derived peptide of the present invention has a small molecular weight and can penetrate the blood - brain barrier . Moreover, it is a small - 10 molecule derived a protein the body, ving an extremely small sid e effect to the human body compared with other developed and synthesized drugs, thereby it has a good clinical application prospect. If the present invention is applicable to clinical practice, it will become a novel neuroprotective drug for preventing and treating central nervous system diseases, providing a new therapeutic direction for patients with nerve 15 damage. F ig. 2 to be published
