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GNAQ TARGETED DSRNA COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION
专利权人:
ALNYLAM PHARMACEUTICALS; INC.
发明人:
GOLLOB, JARED,HINKLE, GREGORY,TOUDJARSKA, IVANKA,BUMCROT, DAVID
申请号:
NZ59361809
公开号:
NZ593618A
申请日:
2009.12.10
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
Disclosed is a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of a G-alpha q subunit (GNAQ) of a heterotrimeric G gene, comprising a sense strand and an antisense strand comprising a region of complementarity complementary to an mRNA encoding the GNAQ, wherein each strand is 15-30 nucleotides in length and wherein the antisense strand is complementary to at least 15 contiguous nucleotides of SEQ ID NO: 1421, as defined in the complete specification.
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