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MEDICINAL FORM WITH MONITORED RELEASE PREVENTING PREVENTING IMPROPER USE
专利权人:
ЛАБОФАРМ ЮРОП ЛИМИТЕД (IE);ЛАБОФАРМ (БАРБАДОС) ЛИМИТЕД (BB);ЛАБОФАРМ ИНК. (CA)
发明人:
РАХМУНИ Милу (CA),САН Винайак (CA),ЖЕРВЭ Соня (CA),СМИТ Дэймон (CA),ДЮФФАЕЙ Фредерик (CA),РАСТОМС Шэмс (CA),ЭЛЬ-ДЖАММАЛЬ Али (CA),БУРСИКО Бобби-Эрнст (CA),БИШАРА Али (CA),НДОНГ Жан-Мишель (CA),ФЕРРЕДА
申请号:
RU2010129907/15
公开号:
RU2010129907A
申请日:
2008.12.16
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A controlled release formulation, comprising:! (a) a core containing superabsorbent material; ! (b) a controlled release membrane surrounding the core; and! (c) a plurality of controlled release microparticles having a pharmaceutically active agent located therein,! where the particles of microparticles are located inside the core, shell, or both the core and the shell, and where the dosage form! (i) when it is intact and exposed to the aquatic environment, the pharmaceutically active agent is released from the dosage form over an extended period of time, and! (ii) when controlled release shell disintegration occurs and the core is exposed to an aqueous environment, the superabsorbent material swells to form a solid gel that traps the microparticles, and the microparticles provide a controlled release of the pharmaceutically active agent. ! 2. The formulation according to claim 1, wherein the microparticles are located inside the core. ! 3. The formulation according to claim 1, wherein the microparticles are located inside the shell. ! 4. The formulation according to claim 1, wherein the microparticles are located inside both the core and the shell. ! 5. The preparative form according to claims 1 to 4, where the core is monolithic. ! 6. The formulation according to claims 1-4, wherein the core comprises a first layer, a second layer and an optional third layer. ! 7. The formulation according to claim 6, wherein the first layer contains microparticles. ! 8. The formulation according to any one of claims 1 to 4, wherein the pharmaceutically active agent is released over a period of at least 12 hours! 9. The dosage form according to any one of claims 1 to 4, where the pharmacist1. Препаративная форма с контролируемым высвобождением, содержащая: ! (a) ядро, содержащее сверхпоглощающий материал; ! (b) оболочку с контролируемым высвобождением, окружающую ядро; и ! (c) множество микрочастиц с контролируемым высвобождением, имеющих расположенный в них фармацевтически
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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