THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
申请号：
EP11781385.7
公开号：
EP2569013B1
申请日:
2011.05.13
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies； and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.
