Cenicriviroc combination therapy for the treatment of fibrosis

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专利权人:

Inc.;Tobira Therapeutics

发明人:

Lefebvre, Eric

申请号：

AU2015314830

公开号：

AU2015314830A1

申请日:

2015.09.11

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Cenicriviroc (CVC) is an orally active antagonist of ligand binding to C-C chemokine receptor type 5 (CCR5) and C-C chemokine receptor type 2 (CCR2). CVC blocks the binding of RANTES, MIP-1α, and MIP-1β to CCR5, and of MCP-1/CCL2 to CCR2. Methods of treating fibrosis and related conditions comprising co-administration of CVC with FXR agonists, high dose vitamin E (>； 400 iU/d), a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, PPAR-γ agonist, PPAR-δ agonist and/or chemokine antagonists are provided herein.

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中国工程科技知识中心

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http://www.ckcest.cn/home/