Disclosed are herein indole and pyrrolo-pyridine oxoacetamide compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). An example of the compounds is 2-(1-((5-chloropyridin-2-yl)methyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment or prevention of a wide range of disorders including pain, autoimmune disorders, disease-states that are accompanied by inflammatory processes, gastrointestinal diseases, pruritus, substance abuse&ndashrelated syndromes, psychiatric disorders, neurological or neurodegenerative disorders, ocular disorders, appetite-related disorders, gynecological disorders, sleep disorders and urinary system disorders.
