VACCINE COMPOSITION COMPRISING AN IMMUNOGENIC PROTEIN AND COMBINATION ADJUVANTS FOR USE IN ELICITING ANTIGEN-SPECIFIC T-CELL RESPONSES

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专利权人:

TheVax Genetics Vaccine Co.; Ltd.

发明人:

Chia-Mao WU,Jiun-Ming Wu,Yi-Tsui Chiu,Yin-Ching Lin,Hsien-Kai Chuang,Fu-Tan Hsieh,Kuan-Ming Chen

申请号：

US15052713

公开号：

US20160250324A1

申请日:

2016.02.24

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen； (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21； and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826.

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