The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.本發明涉及具有針對西格瑪(σ)受體的藥理學活性的化合物,並且更具體地涉及具有這種藥理學活性的氧雜二氮雜螺環化合物,涉及此類化合物的製備方法,涉及包含它們的藥物組成物,並且涉及它們在療法中的用途,特別是針對藥物濫用和成癮。