GOMTSYAN, ARTHUR,LEE, CHIH-HUNG,KOENIG, JOHN R,SCHMIDT, ROBERT,LUKIN, KIRILL,CHAMBOURNIER, GILLES,HSU, MARGARET,LEANNA, M ROBERT,CINK, RUSSEL D,BAYBURT, EROL K
申请号：
NZ59023404
公开号：
NZ590234A
申请日:
2004.06.10
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
A process for preparing a compound having structural formula (1*), wherein the substituents are as defined in the specification is disclosed, wherein process (1) is a process comprising, in toto, the steps of: (a) treating a compound of formula (XII) with trichloroacetyl chloride and triethylamine in dichloromethane to provide a compound of formula (la) and (b) treating the compound of formula (la) with a compound formula (XIII) (shown in the specification) and 1,8-diazabicycloundec-7-ene (DBU) in acetonitrile to provide a compound of formula (1*). Also disclosed are alternate processes for preparing a compound of formula (1*). These compounds of formula (1*) inhibit the VR1 receptor in mammals and are useful for controlling pain.
