A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluo ro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.本發明係關於一種包含化合物1(R)-1-(2,2-二氟苯并[d][1,3]間二氧雜環戊烯-5-基)-N-(1-(2,3-二羥基丙基)-6-氟-2-(1-羥基-2-甲基丙-2-基)-1H-吲哚-5-基)環丙烷甲醯胺及至少一種選自：填充劑、崩解劑、界面活性劑、助流劑及潤滑劑之賦形劑的醫藥組合物，該組合物適於向有需要之患者經口投與以治療CFTR介導之疾病，諸如囊性纖維化。亦揭露用於治療有需要之患者之方法，其包括投與具有化合物1之該醫藥組合物。
