PROBLEM TO BE SOLVED: To provide a preventive and/or therapeutic agent for meibomian dysfunction.SOLUTION: The present invention provides a compound of formula (1) containing sirolimus or the like, or a pharmaceutically acceptable salt thereof (R1 is OH, a dimethylphosphinoyloxy group or the like, R2 and R3 are a methoxy group or the like).SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】マイボーム機能不全の予防及び/又は治療剤の提供。【解決手段】シロリムス等を含む、式(1)の化合物、又はその薬学的に許容される塩。(R1はOH、ジメチルホスフィノイルオキシ基等、R2及びR3はメトキシ基等を示す。)【選択図】なし