Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organisms reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organisms reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In one embodiment an intraluminal medical device comprises a scaffold structure having a luminal surface and an abluminal surface a first layer affixed to the luminal and abluminal surfaces, the first layer including at least one first therapeutic agent and a second layer affixed to the first layer, the second layer including at least one second therapeutic agent in combination with a water soluble polymeric material and a water insoluble polymeric material.
