YAMAMOTO, Hiroshi,YAMAMOTO, Yasuko,KUSUMI, Kensuke,NAGANAWA, Atsushi,OTSUKI, Kazuhiro,SEKIGUCHI, Tetsuya,SHINOZAKI, Koji
申请号：
DK14775353
公开号：
DK2980072T3
申请日:
2014.03.25
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
An object of the present invention is to provide a compound having strong human S1P 2 antagonistic activity in order to develop a useful medicament for therapy of a S1P 2 -mediated disease such as a disease resulting from vascular constriction, fibrosis and respiratory disease. The compound represented by the general formula (I): wherein all the symbols have the same meanings as described in the specification, has a halogen atom or a haloalkyl group and a phenoxy group at certain substitution sites, and thus has strong human S1P 2 antagonistic activity. Therefore, the compound can be a therapeutic agent for a S1P 2 -mediated disease, such as a disease resulting from vascular constriction, fibrosis and respiratory disease.
