Disclosed are systems and methods for clinical trial assessment of skin disease treatment. The disclosure includes obtaining a series of digital images over a period of time, wherein each digital image includes an affected area of the subject； identifying characteristic morphologies and lesions in the affected area of the subject in each of the digital images； classifying each of the detected and segmented morphologies and lesions into one or more identified categories for each of the digital images； assigning a global score to each of the digital images based on a count of the detected and segmented characteristic morphologies and lesions in each of the one or more identified categories； analyzing the global scores of each of the digital images； and making an assessment of the clinical trial based on the analysis of the global scores of each of the digital images.
