Yeo-Jin Jeon;Jeong-Min Kim;Cheol-Hee Kim;In-Sung Song;Nam-Soon Kim;Ga-Hee Ha;So-Young Jeong;Nang-Su Oh;Hyun-Taek Kim
发明人:
Nam-Soon Kim,In-Sung Song,Nang-Su Oh,So-Young Jeong,Ga-Hee Ha,Yeo-Jin Jeon,Jeong-Min Kim,Cheol-Hee Kim,Hyun-Taek Kim
申请号：
US12594843
公开号：
US08278285B2
申请日:
2008.08.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
