NOWE BISPECYFICZNE PRZECIWCIAŁO WIĄŻĄCE SIĘ Z LUDZKIM TLR2 I LUDZKIM TLR4

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专利权人:

Astellas Pharma Inc.

发明人:

TAKEUCHI, SATOSHI,SATO, MASAHITO,SUZUKI, JOTAROU,SOGA, SHINJI,TAKASAKI, JUN,AOYAMA, KOJI,OKUYAMA, CHIE

申请号：

PL15754783

公开号：

PL3112462T3

申请日:

2015.02.27

申请国别(地区):

PL

年份:

2019

代理人:

摘要：

[Problem] To provide a bispecific antibody for preventing or treating an immune inflammatory disease by acting on both human TLR2 and human TLR4 to inhibit human TLR2- and human TLR4-mediated immune inflammatory effects. [Means for Solution] Provided is a bispecific antibody for human TLR2 and human TLR4, including a heavy chain variable region of an anti-human TLR2 antibody consisting of the amino acid sequence of amino acid numbers 1 to 120 of SEQ ID NO: 4； a light chain variable region of an anti-human TLR2 antibody consisting of the amino acid sequence of amino acid numbers 1 to 113 of SEQ ID NO: 6； a heavy chain variable region of an anti-human TLR4 antibody consisting of the amino acid sequence of amino acid numbers 491 to 609 of SEQ ID NO: 4； and a light chain variable region of an anti-human TLR4 antibody consisting of the amino acid sequence of amino acid numbers 625 to 732 of SEQ ID NO: 4.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/