THE PRESENT INVENTION PROVIDES METHODS OF REDUCING THE VIRCIDAL ACTIVITY OF A COMPOSITION COMPRISING A PCV-2 ANTIGEN AS WELL AS ANTIGENIC PREPARATIONS AND IMMUNOGENIC COMPOSITIONS COMPRISING A PCV-2 ANTIGEN, WHEREIN THE VIRUCIDAL ACTIVITY HAS BEEN REDUCED. IN ADDITION, THE PRESENT INVENTION ALSO RELATES TO A METHOD OF INCREASING THE IMMUNOGENICITY OF AN IMMUNOGENIC COMPOSITION COMPRISING A PCV-2 ANTIGEN AS WELL AS IMMUNOGENIC COMPOSITION WITH AN INCREASED IMMUNOGENICITY. (NO SUITABLE FIGURE)