DANIEL VERHOEF,フェルフーフ，ダニエル,PIETER H REITSMA,ライツゥマ，ピーター ハー,METTINE H A BOS,ボス，メッティーネ ハーアー
申请号：
JP2019235197
公开号：
JP2020062039A
申请日:
2019.12.25
申请国别(地区):
JP
年份:
2020
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a recombinant protein including a coagulation factor Xa polypeptide preventing bleeding complications that are associated with anticoagulant therapy using a blood coagulation factor Xa inhibitors and to provide a pharmaceutical composition including the protein.SOLUTION: This disclosure relates to a recombinant protein including a coagulation factor Xa polypeptide with an insertion and/or replacement and/or deletion of at least one amino acid residue and with decreased sensitivity to factor Xa inhibitors and further relates to a pharmaceutical composition that includes the recombinant protein and that is used for a method to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】血液凝固第Ｘａ因子阻害剤による抗凝固療法に伴う出血合併症を予防する、凝固因子Xaポリペプチドを含む組換えタンパク質及び該タンパク質を含む医薬組成物の提供。【解決手段】少なくとも1つのアミノ酸残基の挿入および／または置換および／または欠失を有し第Ｘａ因子阻害剤に対する感受性を減少させた凝固因子Ｘａポリペプチドを含む組換えタンパク質、および該組換えタンパク質を含み阻害剤の抗凝固剤効果を完全にまたは部分的に回復させる方法に使用する医薬組成物。【選択図】なし
