Extracts derived from plants and/or fractions thereof, compositions comprising same and methods and use thereof in protecting tissues from damage caused by toxins are encompassed herein. More particularly, compositions comprising a polar solvent extract and/or a fraction thereof derived from an Inula plant (e.g., Inula helenium) and methods and use thereof in protecting tissues comprising epithelial cells from adverse effects of toxins, particularly exogenous toxins originating from environmental pollution, are encompassed herein.
