SHAH, Kalpana,SMITH, Douglas H.,MOTTE-MOHS, Ross,JOHNSON, Leslie S.,MOORE, Paul A.,BONVINI, Ezio,KOENIG, Scott
申请号：
AU2020200054
公开号：
AU2020200054A1
申请日:
2020.01.03
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020200054A120200130.pdf#####ABSTRACT The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-i and to human PD-I : PD-i mAb 1, PD-i mAb 2, PD-i mAb 3, PDI mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-i mAb 11, PD-i mAb 12, PD-i mAb 13, PD-i mAb 14, or PD-i mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-i -binding molecules that comprise PD-i binding fragments of such anti-PD- antibodies, immunoconjugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1 -binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cell. The present invention also pertains to methods of using molecules that bind PD-i for stimulating immune responses, as well as methods of detecting PD-1.
