BAUMANN, KARLHEINZ,GREEN, LUKE,LIMBERG, ANJA,LUEBBERS, THOMAS,THOMAS, ANDREW
申请号：
PE0020002013
公开号：
PE02502014A1
申请日:
2012.02.28
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to Derivatives of piperidine compounds of formula (i), where I is a heteroaryl Group hetaril Five, Six links, which contains 1 to 3 heteroatoms selected from S and N hetaril II is a heteroaryl Group of six links that contains 1 to 3 heteroatoms selected from S and N, Tre r1 is lower Lower alkyl, alkoxy alkyl R2 is lowerLower alkoxy, halogen, among others R3 is H, alkyl ch2och2 is lower and - - - - - ch2s, CH2O, among others, and is attached to two of the carbon Atoms of the ring, the Union is made with carbon Atoms \ufffda\ufffd and B of the Ring carbon Atoms or with \ufffdc\ufffd and \ufffdd\ufffd Ring M Is the Number 0 - 2 \ufffdo\ufffd is 0 - 2.Preferred compounds are (RAC) - 3 - [(Exo - 8 - 3 - methyl - 5 - [1,2,4] thiadiazole - yl) - 8 - aza Bicyclo [3.2.1] oct - yl] - 3 - (4 - phenyl - 2 - 5 - 4,5,6,7 tetrahydro - yl) - Amine [(RAC) - 8 - Endo (3 - 3 - methyl - 5 - [1,2,4] thiadiazole - yl) - 3-azabicyclo [3.2.1] - Oct 8 - yl] - [8 - (2 - 4 - fluoro chloro phenyl) - 6 - methyl - [1,2,4 triazolo [] - pirid 1,5-a] In - 2 - il - amine.Also refers to a Pharmaceutical composition is useful for the treatment of Alzheimers diseaseSE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDINA DE FORMULA (I), DONDE HETARIL I ES UN GRUPO HETEROARILO DE CINCO, SEIS ESLABONES, QUE CONTIENE DE 1 A 3 HETEROATOMOS ELEGIDOS ENTRE S Y N HETARIL II ES UN GRUPO HETEROARILO DE SEIS ESLABONES QUE CONTIENE DE 1 A 3 HETEROATOMOS ELEGIDOS ENTRE S Y N, ENTRE OTROS R1 ES ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS R2 ES ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO ENTRE OTROS R3 ES H, ALQUILO INFERIOR Y ES -CH2OCH2-, -CH2O-, CH2S- ENTRE OTROS Y ESTA UNIDO A DOS DE LOS ATOMOS DE CARBONO DEL ANILLO, LA UNION SE REALIZA CON LOS ATOMOS DE CARBONO �a� Y � b � DEL ANILLO O CON LOS ATOMOS DE CARBON �c� Y �d� DEL ANILLO m ES EL NUMERO 0-2 �o� ES 0-2. SON COMPUESTOS PREFERIDOS [(RAC)-3-EXO-8-(3-METIL-[1,2,4]TIADIAZOL-5-IL)-8-AZA-BICICLO-[3.2.1]OCT-3-IL]-(4-FENIL-4,5,6,7-TETRAHIDRO-BENZOTIAZOL-2-IL)-A
