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CYCLODEXTRIN-BASED POLYMERS FOR DELIVERING THE THERAPEUTIC AGENTS COVALENTLY BOUND THERETO
专利权人:
发明人:
申请号:
HK11105534.9
公开号:
HK1151467A
申请日:
2005.06.15
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distribution kits containing or relating to the polymeric compounds described herein. The therapeutic agents, e.g. camptothecin, are chemically attached to the cyclodextrin-containing polymer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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