THIS INVENTION RELATES TO A DRUG DELIVERY SYSTEM FOR ADMINISTRATION OF POORLY WATER SOLUBLE PHARMACEUTICALLY ACTIVE SUBSTANCE, A PHARMACEUTICAL COMPOSITION COMPRISING SUCH A DRUG DELIVERY SYSTEM, AND A METHOD FOR THE PREPARATION OF SUCH A DRUG DELIVERY SYSTEM. THE INVENTION ALSO RELATES TO A METHOD FOR CONTROLLING THE PARTICLE SIZE AND/OR PARTICLE SHAPE AND/OR PARTICLE SIZE DISTRIBUTION IN SUCH A DRUG DELIVERY SYSTEM, AND TO A METHOD FOR INCREASING THE DRUG LOADING CAPACITY OF THE PARTICLES. FURTHERMORE THE INVENTION ALSO RELATES TO THE USE OF SUCH A DRUG DELIVERY SYSTEM FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF CANCER. FIGURE 1