Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof

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专利权人:

Guochen Chi

发明人:

Mickle, Travis,Guenther, Sven,Chi, Guochen,Kanski, Jaroslaw,Martin, Andrea K.,Bera, Bindu

申请号：

AU2012328837

公开号：

AU2012328837A1

申请日:

2012.10.25

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

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