The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of an estetrol component at a specific daily dose, optionally in combination with a progestogenic component. The therapy enjoys a statistically significant efficacy combined with a favourable profile for side effects compared to currently available methods for alleviating menopause-associated symptoms.本發明關於一種用於緩解停經相關症狀的荷爾蒙置換療法、相關的化合物及相關的包裝單元，所述治療基於以特定每日劑量對雌性哺乳類施予雌四醇成分，且選擇性地與助孕素類成分併用。與現有用於緩解停經相關症狀可用的方法比較時，所述療法具有統計學上顯著的功效，且同時具有有利的副作用特徵。
