WONG, CHI HUEY,翁启惠,翁啟惠,WU, CHUNG YI,吴宗益,吳宗益,TSAI, MING HUNG,蔡名鸿,蔡名鴻
申请号：
TW104117112
公开号：
TW201609136A
申请日:
2015.05.27
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.本揭示係關於新穎種類之抗CD20單株抗體，其包括在每一Fc上具有相同N-聚醣之抗CD20 IgG分子之均質群體。本發明抗體可自抗CD20單株抗體由Fc醣改造產生。重要的是與未經醣改造之相應單株抗體相比，本發明抗體具有改良之治療價值與增加之ADCC活性及增加之Fc受體結合親和力。
