ABRAMSON RESEARCH CENTER;THE CHILDRENS HOSPITAL OF PHILADELPHIA RESEARCH INSTITUTE;THE CHILDREN'S HOSPITAL OF PHILADELPHIA RESEARCH INSTITUTE
发明人:
WRIGHT, JOHN, FRASER,ZELENAIA, OLGA,HAUCK, BERND,MINGOZZI, FEDERICO,HIGH, KATHERINE, A.
申请号：
EP12746664
公开号：
EP2675484A4
申请日:
2012.02.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
This application relates to the fields of gene therapy and molecular biology. In accordance with the present invention, an adeno-associated virus (AAV) vector comprising an altered capsid protein is provided. More specifically, this invention provides adeno-associated viral vectors comprising protein capsid variants which accelerate vector breakdown and clearance, thereby reducing undesirable immune responses.
