THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES;MARINE POLYMER TECHNOLOGIES INC.;NOVARTIS AG;ADMUNE THERAPEUTICS LLC
发明人:
申请号：
IL20299709
公开号：
IL202997A
申请日:
2009.12.27
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
The invention provides an isolated cell that recombinantly expresses (i) a mammalian interleukin (IL-15), and (ii) a soluble form of a mammalian interleukin-15 receptor alpha (IL-15Ra), a mammalian IL-15Ra, a polypeptide comprising a mammalian IL-15Ra and a first heterologous molecule, or a polypeptide comprising a soluble form of a mammalian IL-15Ra and a second heterologous molecule, wherein the cell expresses at least 150 ng/million cells of mammalian IL-15 per day when cultured in serum-free media. The invention further provides a method of recombinantly producing (i) human IL-15 and (ii) human IL-15Ra or a polypeptide comprising a human IL-15Ra and a heterologous molecule.
