T-cells are generated with enhanced immunostimulatory capabilities for use inself therapy treatment protocols, by utilizing a biodegradable device with abiodegradable support that has one or more agents that are reactive to T-cellsurface moieties. The biodegradable devices are mixed with the T-cellssufficiently so that the one or more agents cross-link with the T-cells~surface moieties and deliver a signal to the T-cells to enhanceimmunostimulatory capabilities.
