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Optically active fluconazole analogues containing thiophenes as antifungal agents
专利权人:
Hanumant Bapurao Borate
发明人:
Hanumant Bapurao Borate,Sangeshwer Prabhakar Sawargave,Subhash Prataprao Chavan,Mohan Anand Chandavarkar,Ramakrishnan Ramacahndran Iyer,Amit Chandrakant Tawte,Deepali Damodar Rao
申请号:
US14264574
公开号:
US09447082B2
申请日:
2014.04.29
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention discloses optically active compounds of Formula (1a) or Formula (1b),wherein R1 and R2 are independently selected from the group consisting of hydrogen and a halogen selected from the group consisting of fluorine, chlorine, bromine, and iodine and wherein (a) R3 and R4 are independently selected from the group consisting of hydrogen and an alkyl group having a linear or branched chain having 1 to 20 carbon atoms, or (b) R3 and R4 together form a cycloalkyl ring having 3 to 10 carbon atoms fused to the thiophene ring and wherein R5 is CN or COOR′, where R′ is methyl or ethyl. The compounds of Formula (1a) or Formula (1b) may be used in pharmaceutical compositions for treating fungal infections.
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