A VECTOR FOR EXPRESSING FC DOMAIN OF CANINE IGG ON THE CELL SURFACE, A HOST CELL TRANSFORMED WITH SAID VECTOR AND A METHOD FOR MANUFATURING VACCINE AGAINST CANINE DISEASES USING SAID HOST CELL
PURPOSE: A vector for surface expression of canine IgG Fc domain is provided to easily produce a vaccine with excellent immunity for the virus for various dog disease-related viruses. CONSTITUTION: A vector for surface expression of canine IgG Fc domain contains a gene encoding the domain of sequence number 1 and a gene encoding a trans-membrane domain of mouse IgG protein of sequence number 2. The vector is Canine Fc/pcDNA3 vector. A method for manufacturing a vaccine for dog disease-related virus comprises: a step of infecting the virus with a coat into a host cell which is transformed by the vector and proliferating the virus； and a step of manufacturing a live vaccine or inactivated vaccine using the virus. [Reference numerals] (AA) Lytic enzymes； (BB) Perforin； (CC) Granzyme； (DD) Neutroph； (EE) NK cells； (FF) Target cells； (GG) Eosinophil； (HH) Fc acceptors； (II) Surface antigen(Ag)； (JJ) Ab combined with Ag and Fe acceptors； (KK) Macrophage본 발명은 개 면역글로불린 지(Immunoglobulin G； 이하 “IgG"라 한다)의 에프씨(Crystallized Fragment 이하 ”Fc“라 한다) 도메인의 세포 표면 발현용 벡터, 상기 벡터에 의해 형질전환된 숙주세포 및 상기 숙주세포를 이용한 개 질병 관련 바이러스에 대한 백신의 제조방법에 관한 것이다.
