Crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl) -1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino] -pyrimidin-4-yl}-1-methyl-urea and salts thereof.
Berghausen, Joerg,Kapa, Prasad Koteswara,McKenna, Joseph,Slade, Joel,Wu, Raeann,Du, Zhengming,Stowasser, Frank
申请号：
AU2014221268
公开号：
AU2014221268A1
申请日:
2014.09.05
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014221268A120140925.pdf#####H:\dx -n vlovero RPorthl\DCCRBR\ 5 Loc4/09/20!4 ABSTRACT The present technology provides novel anhydrous and hydrated crystalline forms of 3-(2,6dichi oro-3 ,5-dim ethoxy-phenyl)-I -(6-[4-(4-ethyl-piperazin- 1-yl)-phenylamino] -pyrimidin4-yl}-1-methyl-urea, amorphous and anhydrous crystalline polymorphs of its monophosphoric acid salt, and the hydrochloride salt, including its dihydrate. The present technology further provides methods for preparing the various forms, compositions containing them, and methods of treatment employing them.
