PROBLEM TO BE SOLVED: To provide an orally disintegrating olanzapine tablet in which the increase of analogues by oxidative degradation or a degradation mechanism thereof is reduced over the long time.SOLUTION: The invention provides an orally disintegrating olanzapine tablet preserved in a packaging form where a drying agent having a deoxidation function which utilizes the oxidation mechanism of organic substances is enclosed. Preferably, the drying agent has a deoxidation function and is enclosed in an organic deoxidant, and preferably, the drying agent is also used in combination with the drying agent having a deoxidation function. Preferably, the orally disintegrating tablet has a packaging form of a pillow package or a bottle package. The orally disintegrating olanzapine tablet in which excellent stability is imparted reduces the temporal increase of many degradation products (analogue B, analogue C, thiolactam body, lactam body, and the like) derived from olanzapine, by the packaging form.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】酸化分解又はその分解機構により類縁物質の増加するのを長期間にわたり軽減されたオランザピンの口腔内崩壊錠の提供。【解決手段】有機物の酸化機構を利用した脱酸素機能を有する乾燥剤が封入された包装形態中に保存されたオランザピンの口腔内崩壊錠。前記乾燥剤としては、有機系脱酸素剤に乾燥剤が同封された、脱酸素機能付き乾燥剤であることが好ましく、更に、脱酸素機能付き乾燥剤に乾燥剤を併用することも好ましい。前記口腔内崩壊錠は、包装形態がピロー包装又は瓶包装であることが好ましい。前記包装形態により、オランザピンに由来する多くの分解物(類縁物質B、類縁物質C、チオラクタム体、ラクタム体等)の経時的増加を抑え、優れた安定性を付与したオランザピンの口腔内崩壊錠。【選択図】なし
