SAIS CRISTALINOS DA AMIDA DO ÁCIDO (4S,4AS,5AR,12AS)-4-DIMETILAMINO-3,10,12,12A-TETRA-HIDROXI-7-[(METOXI(METIL)AMINO]-METIL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTA-HIDRO-NAFTACENO-2-CARBOXÍLICO E MÉTODOS DE UTILIZAÇÃO DOS MESMOS
ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED;PARATEK PHARMACEUTICALS, INC.
发明人:
CATHERINE COULTER,SEAN M. JOHNSTON,FARZANEH SEYEDI
申请号：
PT12782600
公开号：
PT2707003T
申请日:
2012.05.14
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethyl-amino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene- 2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
