GILMER JOHN FRANCIS,LEDWIDGE MARK,O FLYNN Pat,HARMON SHONA,RADOMSKI MAREK,MARTIN CARLOS MEDINA
申请号：
IN2542/KOLNP/2013
公开号：
IN2013KN02542A
申请日:
2013.08.16
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
A compound having the structural formula (I) and pharmaceutically acceptable salt and/or hydrates thereof, (I) wherein Y is an arylester or an C1- C8 alkylaryl ester, selected from the group consisting of: benzene, toluene, xylene, benzoic acid, benzoate, nicotinate, isonicotinate and halobenzene, which can be unsubstituted or substituted with at least one nitric oxide releasing group and/or at least one of hydroxide, -Cl, -Br, a C1- C8 alkyl, benzyl, a C1- C8 alkoxy, benzyloxy, -NHC(O)R, -NH2,-NO2,-ONO2, -(CH2)n ONO2, -OC(O)[(CH2)m]cyclic ONO2, -OCOArONO2,-OCOAr (CH2)m ONO2 or a C1- C5 haloalkyl ester, wherein R is a C1- C8 alkyl or a C1- C8 alkoxy group, n=1-8 and m=3- 10, to produce a super-aspirin effect.
