An infant, joint compression device and methods of use including decreasing the length of stay in a neonatal intensive care unit and/or increasing bone density of a premature infant are disclosed. A device can include an elongated, generally cocoon-shaped device pod having a head pod end, a foot pod end and a pod interior extending between the head pod end and the foot pod end; a head opening at the head pod end and communicating with the pod interior; and a pod slit extending from the head opening toward the foot pod end and communicating with the pod interior.