改良型高濃度抗ＴＮＦアルファ抗体液体製剤

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专利权人:

アッヴィ バイオテクノロジー リミテッド

发明人:

ミヒヤエル・ノイ,マルクス・ツオープ,カルステン・ベーバー,ローラ・レツデン,ボルフガング・フラウンホーフアー

申请号：

JP20160006834

公开号：

JP6062582(B2)

申请日:

2016.01.18

申请国别(地区):

日本

年份:

2017

代理人:

摘要：

The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/