LHの精製

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专利权人:

メルク セローノ ソシエテ アノニム

发明人:

パラディージ,ジャンフランコ,ロッシ,マーラ,スカグリア,ラウラ

申请号：

JP2001562555

公开号：

JP4959898B2

申请日:

2001.01.22

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified LH obtained from the process is particularly high and amounting to about 25.000 IU/mg.

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