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METHOD FOR PRODUCING MEDICINAL FORMS CONTAINED IN THE STOMACH CONSISTING OF A SET OF PARTICLES
专利权人:
МЕЛИАТИС (FR)
发明人:
КИРКОРЯН Джоел Сильвиан Мишель (FR)
申请号:
RU2013117920/15
公开号:
RU2013117920A
申请日:
2011.10.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of producing particles with a low density, comprising the steps of: (i) obtaining a powder mixture containing a swellable agent; (ii) granulating the powder from step (i) with a lipophilic agent-containing solution for granulation into granules; (iii) drying the granules with stage (ii) .2. The method according to claim 1, further comprising a step (iv) of compressing the granules from step (iii). The method according to any one of claims 1 and 2, further comprising a step (v) of coating the granules obtained from step (ii) or step (iii). 4. The method according to any one of claims 1 and 2, wherein the active ingredient is added to the starting powder from step (i) and / or the granulation solution from step (ii), preferably to the starting powder from step (i), and / or applied to granules obtained in stage (iii) .5. The method according to any one of claims 1 and 2, wherein a binder is added with the starting material of step (i) and / or the granulation solution from step (ii), preferably in the starting powder from step (i). 6. The method according to any one of claims 1 and 2, wherein the swelling aid is a cellulose derivative with a molecular weight of from 4,000 to 2,000,000, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, superporous hydrogels; polyethylene oxides, polyethylene; polypropylene; polyvinyl chloride; polycarbonates; polystyrenes; polyacrylates; carboxyvinyl polymers; polyvinyl alcohols; glucans; scleroglucans; chitosans; mannans; galactomannans; gums; xanthan gums; carrageenans; amylase; alginic acids, acrylates, methacrylates, acrylic / methacrylic copolymers, polyanhydrides, polyamino acids, copolymers of methyl vinyl ethers and1. Способ получения частиц с низкой плотностью, включающий стадии:(i) получения порошковой смеси, содержащей способствующее разбуханию средство;(ii) гранулирования порошка со стадии (i) с содержащим липофильное средство раствором для гранулирования в гранулы;(iii) высушивани
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