5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1 H-ISOINDOL-1 -ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA
Some new compounds, including salts of such compounds that can be accepted medically, have been published.1. Inhibiting the activities of dimethyl gamma phosphate (PI3 Kuwaiti dinar) and gamma phosphate dimethyl (PI3KY)；It is very useful for the treatment and/or prevention of clinical diseases including asthma and chronic obstructive pulmonary disease.A. There are disclosed certain novel compounds (including pharmaceutically acceptable salts there) (i) that inhibit phosphatidylinositol 3-kinase gamma (pi3kd) and phosphatidylinositol 3 - Kinase Gamma (3) Activity, to their utility in processing and/or preventing clinical conditions including breathory diseases, such as asthma and chronic imposing nuclear disease (COPD),To their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.Se dan a conocer ciertos compuestos nuevos (que incluyen sales farmacéuticamente aceptables de estos), que inhiben la actividad de fosfatidilinositol¿¿3-cinasa gamma (PI3Kd) y fosfatidilinositol¿¿3-cinasa gamma (PI3Ky), a su utilidad en el tratamiento y/o la prevención de afecciones clínicas que incluyen enfermedades respiratorias, tales como el asma y la enfermedad pulmonar obstructiva crónica (EPOC), a su uso en terapia, a composiciones farmacéuticas que los contienen y a procesos para preparar tales compuestos.There are disclosed certain novel compounds (including pharmaceutically acceptable salts thereof) (I) that inhibit phosphatidylinositol 3-kinase gamma (PI3Kd) and phosphatidylinositol 3-kinase gamma (¿¿3¿¿) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
