WU, Kui,LI, Fuqiang,HOU, Yong,ZHU, Shida,YE, Xiaofei,LIANG, Yan
申请号：
EP15907626
公开号：
EP3372686A4
申请日:
2015.11.05
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided are a biomarker related to detection of lung adenocarcinoma and a use thereof. Also provided is a method for in vitro detection of lung adenocarcinoma, comprising: acquiring a first mutation level from mutation levels of one or more biomarkers at a first site of a subject, wherein the biomarker comprises at least one the following genes: TP53, EGFR, LRP1B, KRAS, PTPRD, STK11, SMAD2, PIK3CA, BRAF, FLT1, RHPN2, GLI3 and MRC2； comparing the first mutation level with a first reference level； and when there is a distinct difference between the first mutation level and the first reference level, determining that the subject has a lung adenocarcinoma, wherein the first reference level is a mutation level of the biomarker at a first site of a normal individual.
