Tets, Viktor Veniaminovich;Tets, Georgy Viktorovich
发明人:
申请号：
EP16773558.8
公开号：
EP3315501A4
申请日:
2016.04.06
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The invention relates to the field of organic chemistry and medicine, and more particularly to synthetic substances of the pyrimidine series, namely 2-chloro-5-phenyl-5 H- pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives, having antiviral activity. Claimed are a drug with antiviral activity against HIV infection and hepatitis B virus, containing 2-chloro-5-phenyl-5H-pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives of the general formula shown, where: X is selected from the group: H, NO 2 , Hal, OMe； R1 is selected from the group: Cl, OH； and R2 is selected from the group: Cl, SH, OH； and a drug with antiviral activity against HIV infection, containing a 2-chloro-5-phenyl-5H-pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivative of the general formula shown, where: X is selected from the group: H, NO 2 , Hal, OMe； R1 is selected from the group: Cl, OH； and R2 is selected from the group: Cl, SH, OH in combination with a reverse transcriptase inhibitor selected from Retrovir, or in combination with a protease inhibitor selected from Lopinavir, in an effective amount. The result is an effective drug with antiviral activity.
