Targeted TGFβ inhibitors

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专利权人:

Merck Patent GmbH

发明人:

Kin-Ming Lo

申请号：

US14618454

公开号：

US09676863B2

申请日:

2015.02.10

申请国别(地区):

US

年份:

2017

代理人:

摘要：

This invention relates generally to bifunctional molecules including (a) a TGFβRII or fragment thereof capable of binding TGFβ and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1), uses of such molecules (e.g., for treating cancer), and methods of making such molecules.

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