A urinary catheter and a method of its manufacture are disclosed. The urinary catheter comprises a tubular shaft extending between an insertion end and a discharge end, the tubular shaft being formed of at least two materials having different properties. The materials are arranged substantially separated from each other in distinct zones (ZS,ZH), wherein at lesdt one of these distinct zones extends over essentially the entire length of the tubular shaft and at least one of the width and thickness of said zones varies over the length of the tubular shaft, to form two or more uniform sections (S,H) of the tubular shaft having various relative amounts of said materials, and wherein at least one transition between two such uniform sections is formed by at least one transition section (T) providing a gradual transition between the uniform sections. The catheter can e.g. be produced by intermittent extrusion.