Disclosed herein is a cannula assembly for directing the flow of material from an organ chamber e.g. blood from the left chamber of the heart and methods of placing the cannula assembly in fluidic communication with the chamber. The cannula assembly includes an elongate tubular member (110) and a coupling assembly (120) disposed at the distal end of elongate tubular member. The elongate tubular member includes a lumen extending from a distal opening at the distal end to a proximal opening at the proximal end. The coupling assembly includes a retaining element (122) and a retention member (124) configured to cooperate with each other and with the portion of the organ wall surrounding the opening in the wall to couple or anchor cannula system (100) to the wall and to provide fluidic communication between the distal opening of the elongate tubular member and the organ chamber.
