HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS
Christopher R. MCCURDY,Christophe MESANGEAU,Frederick T. CHIN,Michelle L. JAMES,Bin SHEN,Sanjiv GAMBHIR,Sandip BISWAL,Deepak BEHERA
申请号：
US14196483
公开号：
US20140328755A1
申请日:
2014.03.04
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method for localizing and quantifying S1R role in nociceptive processing for providing a guide to providing an analgesic therapy of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III′, or IV′:
