The present invention provides an electromagnetic wave therapy device and an immunotherapy method thereof, which sense an ambient temperature and a body temperature of a patient by a sensing unit, thereby generating a sensing signal. A control unit, based on indication information, sensing signals and finding a corresponding spectrum indication signal in the database. The baseband unit in the treatment device generates the therapeutic spectrum content corresponding to different waveforms, frequencies, amplitudes or timetable according to the therapeutic spectrum content, and then uses a radio frequency unit emitting a millimeter-wave at a frequency between 56 GHz and 65 GHz to become a millimeter-wave irradiation source, radiates a patient with a desired location to be treated, and allows the patient to perform a millimeter-wave immunotherapy program by radiating the millimeter-wave treatment device with a non-invasive way to achieve the bodys immune cells performance of the purpose and to control and change the human immune system.
